0853. Elevated levels of soluble rage predict impaired alveolar fluid clearance in a translational mouse model of acute respiratory distress syndrome (ARDS)
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چکیده
Introduction Receptor for advanced glycation endproducts (RAGE) is a transmembrane pattern-recognition receptor of the immunoglobulin superfamily that is abundantly expressed in the lung and primarily located on the basal surface of alveolar type I cells. RAGE is implicated in ARDS as an important pathway to alveolar inflammation and, when its soluble form sRAGE is assayed in plasma or pulmonary edema fluid, as a marker of AT I cell injury [1]. Functional activity of AT 1 cells can be assessed by the measurement of alveolar fluid clearance (AFC) rate [2], but the relationship between sRAGE plasma levels of sRAGE and AFC rates has never been investigated.
منابع مشابه
Elevated levels of soluble RAGE predict impaired alveolar fluid clearance in a translational mouse model of acute respiratory distress syndrome
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Inhibition of receptor for advanced glycation end-products (RAGE) improves alveolar fluid clearance and lung injury in a mouse model of acute respiratory distress syndrome (ARDS)
Rationale The receptor for advanced glycation end-products (RAGE) is a transmembrane multipattern receptor abundantly expressed on the basal surface of alveolar type (AT) I cells. RAGE is implicated in ARDS-associated alveolar inflammation [1,2], but its precise roles in lung injury remain unknown. It has been shown recently that RAGE axis could impact alveolar fluid clearance (AFC) through the...
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